کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486862 1114396 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral and IV Dosing: A Method to Determine the Compartment of Drug Elimination for Two-Compartment Models
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Oral and IV Dosing: A Method to Determine the Compartment of Drug Elimination for Two-Compartment Models
چکیده انگلیسی
It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper a new modelling strategy is examined whereby the compartment of elimination may be identified uniquely for the case of two-compartment models. The two models examined predict different profiles in the absorption phase of an oral profile. An in vivo data set is provided that favours a peripheral elimination explanation of its observed pharmacokinetics, based on the 'goodness of fit'.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 6, June 2008, Pages 2036-2040
نویسندگان
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