کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487057 1114402 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of Monte Carlo Simulation-Based Photon Migration for Enhanced Understanding of Near-Infrared (NIR) Diffuse Reflectance. Part II: Photon Radial Diffusion in NIR Chemical Images
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Application of Monte Carlo Simulation-Based Photon Migration for Enhanced Understanding of Near-Infrared (NIR) Diffuse Reflectance. Part II: Photon Radial Diffusion in NIR Chemical Images
چکیده انگلیسی
This is the second of a series of articles applying Monte Carlo simulation-based photon migration as a means of enhancing understanding of near-infrared (NIR) diffuse reflectance in pharmaceutical analysis. This work utilizes Monte Carlo simulation to explore photon movement along the radial direction, as a means of investigating the potential 2-D spatial distortion in NIR chemical images caused by photon radial diffusion. Simulations indicate that the physical sample represented by an observed pixel in an image contributes 17% of the spectral information, while the remaining contribution comes from a radial area around the observed pixel about 500 mm wide. Empirical measurements on a two-medium sample (i.e., Teflon films with different thicknesses laid on the top of a pure theophylline compact) were used to confirm the effect of photon radial movement on a physical feature in an NIR chemical image, that is, edge blurring. As a means of edge clarification, a preliminary Monte Carlo simulation-based deconvolution filter was developed and tested for its efficacy on sharpening the physical feature and maintaining the original chemical information in a measured NIR chemical image. The initial success of the deconvolution filter highlights the potential to develop a filter for practical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 10, October 2010, Pages 4174-4182
نویسندگان
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