کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487072 | 1114402 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spinning Disc Processing Technology: Potential for Large-Scale Manufacture of Chitosan Nanoparticles
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Mass production of nanoparticles using a reliable cost-effective approach is a challenge in the pharmaceutical industry. In this study, the spinning disc processing (SDP) technology was used to fabricate chitosan nanoparticles, with a view to commercially produce chitosan nanoparticle-based drug delivery platforms. Chitosan solution (0.25%, w/v, in dilute acid, 27.5 mL, 1.5 mL/s) was intensely mixed with sodium tripolyphosphate solution (0.10%, w/v, in water, 20mL, 1.1mL/s) on the spinning disc (1000rpm). Transmission electron microscopy and dynamic light scattering data confirmed that the nanoparticles (20 ± 3 nm) were comparable in size and shape to those synthesised using a beaker and magnetic stirrer (31 ± 13 nm). Larger nanoparticles (131 ± 5 nm) were produced by increasing the chitosan and TPP feed concentrations to 0.5% and 0.125%, respectively. Drug loading further increased the size of the nanoparticles, with N-acetyl cysteine (NAC) having a greater effect (403 ± 4 nm) than paracetamol (165 ± 4 nm). Co-loading of both drugs increased the size of the particles to the micron range. In conclusion, the SDP is a robust technology capable of expanding the production of blank and drug-loaded chitosan nanoparticles for the biomedical and pharmaceutical industries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 10, October 2010, Pages 4326-4336
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 10, October 2010, Pages 4326-4336
نویسندگان
Jing Wen Loh, Jessica Schneider, Michelle Carter, Martin Saunders, Lee-Yong Lim,