کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487098 1114403 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spray‐dried carrier‐free dry powder tobramycin formulations with improved dispersion properties
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Spray‐dried carrier‐free dry powder tobramycin formulations with improved dispersion properties
چکیده انگلیسی
Tobramycin was spray dried at different temperatures from different water to isopropanol feed ratios (0:100-20:80) in order to obtain dry powder formulations for inhalation. The spray‐dried powders were characterized for their physicochemical properties including crystallinity, morphology, density, water content, and particle size distribution using X‐ray powder diffraction, scanning electron microscopy, tapped density measurements and laser diffraction. Aerosol performance was studied by dispersing the powders into a Multi‐Stage Liquid Impinger with an Aerolizer® device. The results indicate that formulations spray dried at temperatures below 200°C exhibited poor powder flow properties and were therefore unlikely to display optimal aerosolisation characteristics. Nevertheless, it is interesting to note that the presence of water in the suspensions used for spray‐drying markedly enhanced the fine particle fraction, which was about 37% for the raw tobramycin and about 57% for a powder obtained from a suspension containing 2% (v/v) water. Overall, this latter formulation was shown to keep its initial particle size distribution and aerodynamic behaviour for 12 months of storage at 40°C and 75% RH. These new carrier‐free formulations provide an attractive alternative for delivering high doses of antibiotics directly to the site of infection while minimising systemic distribution
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1463-1475
نویسندگان
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