کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487406 1114414 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine
چکیده انگلیسی
It has been suggested that agglomeration of aluminum salt adjuvant particles during freezing and drying can cause loss of immunogenicity of vaccines formulated with such adjuvants. In this study, we tested this hypothesis and examined the immune response in a murine model to various liquid, freeze‐thawed, and lyophilized vaccine formulations, using lysozyme as a model antigen. The various processing techniques and excipient levels resulted in a wide range of particle size distributions (PSDs) and antigen-adjuvant binding levels. Anti‐lysozyme titers were independent of the PSD for vaccines adjuvanted with either aluminum hydroxide or aluminum phosphate and also were unaffected by the level of antigen binding to the adjuvant. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5252-5262, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 12, December 2008, Pages 5252-5262
نویسندگان
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