کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487416 | 1114414 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of DSâ96, an Alkylpolyamine Lipopolysaccharide Sequestrant, in Rodents
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The pharmacokinetics of DSâ96, an Nâalkylhomospermine analog designed to sequester bacterial lipopolysaccharides, has been determined in rodent species. The elimination halfâlife in mice and rats are about 400 and 500 min, respectively, with other PK parameters being quite similar in the two rodent species. Interestingly, the mouse intravenous plasma concentration time curves exhibit an apparent absorption phase. While the rat intravenous data did not exhibit a pronounced apparent absorption phase immediately following injection, plasma levels did increase between 10 and 30 min following an expected drop from time 0 to 5 min. The data are consistent with firstâpass uptake, possibly by the lung, with back diffusion as a function of time. The observed Cmax values of 1.36 µg/mL in the mouse intraperitoneal model suggest that a plasma concentration of 0.5-1 µg/mL corresponds to complete protection for a 200 ng/animal dose of intraperitoneally administered LPS in the Dâgalactosamineâprimed model of endotoxinâinduced lethality. © 2008 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 97:5376-5385, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 12, December 2008, Pages 5376-5385
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 12, December 2008, Pages 5376-5385
نویسندگان
Anurupa Shrestha, Rongti Li, Diptesh Sil, Neha N. Pardeshi, Nancy Schwarting, Karl S. Schorno, Roger A. Rajewski, Apurba Datta, Sunil A. David,