کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487416 1114414 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of DS‐96, an Alkylpolyamine Lipopolysaccharide Sequestrant, in Rodents
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Pharmacokinetics of DS‐96, an Alkylpolyamine Lipopolysaccharide Sequestrant, in Rodents
چکیده انگلیسی
The pharmacokinetics of DS‐96, an N‐alkylhomospermine analog designed to sequester bacterial lipopolysaccharides, has been determined in rodent species. The elimination half‐life in mice and rats are about 400 and 500 min, respectively, with other PK parameters being quite similar in the two rodent species. Interestingly, the mouse intravenous plasma concentration time curves exhibit an apparent absorption phase. While the rat intravenous data did not exhibit a pronounced apparent absorption phase immediately following injection, plasma levels did increase between 10 and 30 min following an expected drop from time 0 to 5 min. The data are consistent with first‐pass uptake, possibly by the lung, with back diffusion as a function of time. The observed Cmax values of 1.36 µg/mL in the mouse intraperitoneal model suggest that a plasma concentration of 0.5-1 µg/mL corresponds to complete protection for a 200 ng/animal dose of intraperitoneally administered LPS in the D‐galactosamine‐primed model of endotoxin‐induced lethality. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5376-5385, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 12, December 2008, Pages 5376-5385
نویسندگان
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