کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487486 1114418 2008 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chitin-silicon dioxide coprecipitate as a novel superdisintegrant
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Chitin-silicon dioxide coprecipitate as a novel superdisintegrant
چکیده انگلیسی
Chitin-silica represents a potentially useful superdisintegrant in many pharmaceutical applications. The “intimate” association between chitin and silica, without evidence of chemical reaction, creates an insoluble, hydrophilic, highly absorbent inert material. The new superdisintegrant is characterized by superiority in water uptake and water penetration, with no gelling hindrance effects, as well as compatibility with pharmaceutical drugs. In addition, it has an outstanding functionality that does not depend on swelling properties, as in the case of most conventional superdisintegrants. Chitin-silica offers good compressibility and compactability characteristics that may allow it to function as a pharmaceutical filler. Studies have shown that chitin-silica, as a superdisintegrant, is effective at all concentrations tested in tablet formulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4955-4969
نویسندگان
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