کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487509 | 1114419 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Development of Thermally Assisted Particle Manipulation and Thermal Nanointeraction Studies as a Means of Investigating Drugâpolymer Interactions
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Development of Thermally Assisted Particle Manipulation and Thermal Nanointeraction Studies as a Means of Investigating Drugâpolymer Interactions The Development of Thermally Assisted Particle Manipulation and Thermal Nanointeraction Studies as a Means of Investigating Drugâpolymer Interactions](/preview/png/2487509.png)
چکیده انگلیسی
This investigation outlines the development of two novel techniques, thermally assisted particle manipulation and thermal nanointeraction studies, to examine the interaction between materials during heating. Dispersions of paracetamol in polyethylene glycol 6000 were prepared and studied using microthermal analysis in a range of modes. The localised thermomechanical analysis (LâTMA) responses showed intermediate responses compared to the pure materials. Thermally assisted particle manipulation was used to place a single particle of PEG on the paracetamol surface and the assembly analyzed using LâTMA as a function of position, with the intermediate response seen at the interface between the two materials. Thermal nanointeraction studies, whereby nanosampled PEG was heated in the immediate proximity of the paracetamol, indicated that the process was kinetically controlled and could be interpreted in terms of the molten PEG influencing the apparent melting of the paracetamol. Nearâfield photothermal IR was used to identify the nature of the material on the probe tip; we provide the first quantitative evaluation of the amount sampled when carrying out thermally assisted nanosampling (circa 500 fg). The investigation has therefore demonstrated that these methods maybe used as a novel approach to studying thermal interactions between pharmaceutical materials. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 97:1551-1563, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 4, April 2008, Pages 1551-1563
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 4, April 2008, Pages 1551-1563
نویسندگان
Ljiljana J. Harding, Mike Reading, Duncan Q.M. Craig,