کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487516 1114419 2008 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State
چکیده انگلیسی
Though there is an advantage in using the higher solubility amorphous state in cases where low solubility limits absorption, physical instability poses a significant barrier limiting its use in solid oral dosage forms. Unlike chemical instability, where useful accelerated stability testing protocols are common, no methodology has been established to predict physical instability. Therefore, an understanding of the factors affecting crystallization from the amorphous state is not only important from a scientific perspective but also has practical applications. Crystallization from the amorphous matrix has been linked to the molecular mobility in the amorphous matrix and recent research has focused on developing the link between these two fundamental properties of glass forming materials. Although researchers have been actively working in this area for some time, there is no current review describing the present state of understanding of crystallization from the amorphous state. The purpose of this review therefore is to examine the roles of different factors such as molecular mobility, thermodynamic factors, and the implication of different processing condition, in crystallization from the amorphous state. We believe an increased understanding of the relative contributions of molecular mobility and processing conditions are vital to increased usage of the amorphous state in solid oral dosage forms. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1329-1349, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 4, April 2008, Pages 1329-1349
نویسندگان
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