کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487551 1114422 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Solid-State Chemist's View of the Crystal Polymorphism of Organic Compounds
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
A Solid-State Chemist's View of the Crystal Polymorphism of Organic Compounds
چکیده انگلیسی
In a survey of some structural and energetic aspects of crystal polymorphism, definitions are proposed, and a method for generating an unequivocal fingerprint of the cohesive pattern of an organic crystal structure is presented. The method identifies the electronic nature of molecule-molecule interactions in crystals, and its application requires a minimal training in basic crystallography and molecular modeling. The analysis suggests that thermodynamic and physical properties of polymorphs of organic crystals are quite often very similar, and sometimes depend on morphology as well as on crystal structure. It is also suggested that real polymorphism should be distinguished from the many defective or modulated structural variations often appearing in the crystallization of weakly bound molecular materials. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2232-2241, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2232-2241
نویسندگان
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