کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487556 1114422 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Single-Droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 2: Drying Kinetics and Particle Formation From Microdroplets of Aqueous Mannitol, Trehalose, or Catalase
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Single-Droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 2: Drying Kinetics and Particle Formation From Microdroplets of Aqueous Mannitol, Trehalose, or Catalase
چکیده انگلیسی
A single droplet drying acoustic levitator has been used to examine the drying behavior of droplets of pharmaceutically relevant solutes used to produce protein‐loaded particles via spray‐drying. The drying behavior of solution droplets of mannitol, trehalose, or catalase was determined. Evidence of super‐saturation of the solute in the droplet surface up to the critical point of drying was obtained. The trehalose achieves a lower degree of super‐saturation than does the mannitol before precipitating at the droplet surface. This results in a shorter duration of the constant‐rate period, but protracted further drying of this amorphous material. Mannitol achieved a higher degree of super‐saturation, and a later critical point with shorter falling‐rate period. Measurements of dried particle radius showed that both solutes form hollow particles. The catalase formed holed, hollow particles with characteristic drying rate profiles that correlated well with developing particle morphology. A strong similarity between the morphologies of dried particles of mannitol, trehalose, or catalase produced either in the levitator or in a spray‐dryer was found. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2284-2295, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2284-2295
نویسندگان
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