کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487566 | 1114422 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folateâreceptorâtargeted liposomes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Phospholipids have been extensively evaluated as an anchor for both PEGylation and receptorâtargeting in liposomal formulations. However, cholesterol, another important component in biomembranes, has not been fully investigated as an alternative anchor. In this study, the potential role of cholesterol for anchoring PEG and folate was investigated. Cholesterol derivatives were synthesized for PEGylation (mPEGâcholesterol) and folate receptor (FR) targeting (folateâPEGâcholesterol) and incorporated into the bilayer of FRâtargeted liposomal doxorubicin. The colloidal stability of these cholesterol derivativeâcontaining liposomes was superior to nonâPEGylated liposomes, indicating that steric barrier provided by mPEGâcholesterol can efficiently inhibit aggregation of liposomes. FRâtargeting activity of these liposomes was demonstrated by in vitro cellâbinding studies on FRâoverexpressing KB cells. In addition, in vivo circulation of cholesterolâanchored liposomes was prolonged compared to nonâPEGylated liposomes. These studies suggest that cholesterol is a viable bilayer anchor for synthesis of PEGylated and FRâtargeted liposomes. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2424-2435, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2424-2435
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2424-2435
نویسندگان
Xiaobin B. Zhao, Natarajan Muthusamy, John C. Byrd, Robert J. Lee,