Efficient Co-crystal Screening Using Solution-Mediated Phase Transformation

ABSTRACTWe have extended the established physical stability treatment for hydrates/solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 990–995, 2007