کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487727 | 1114429 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymerâinduced heteronucleation
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The selection and discovery of new crystalline forms is a longstanding issue in solidâstate chemistry of critical importance because of the effect molecular packing arrangement exerts on materials properties. Polymerâinduced heteronucleation has recently been developed as a powerful approach to discover and control the production of crystal modifications based on the insoluble polymer heteronucleant added to the crystallization solution. The selective nucleation and discovery of new crystal forms of the wellâstudied pharmaceuticals flurbiprofen (FBP) and sulindac (SUL) has been achieved utilizing this approach. For the first time, FBP form III was produced in bulk quantities and its crystal structure was also determined. Furthermore, a novel 3:2 FBP:H2O phase was discovered that nucleates selectively from only a few polymers. Crystallization of SUL in the presence of insoluble polymers facilitated the growth of form I single crystals suitable for structure determination. Additionally, a new SUL polymorph (form IV) was discovered by this method. The crystal forms of FBP and SUL are characterized by Raman and FTIR spectroscopies, Xâray diffraction, and differential scanning calorimetry. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2978-2986, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 11, November 2007, Pages 2978-2986
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 11, November 2007, Pages 2978-2986
نویسندگان
Adam L. Grzesiak, Adam J. Matzger,