کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487737 | 1114429 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetic prediction for intravenous βâlactam antibiotics in pediatric patients
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A method for predicting pharmacokinetics in pediatric patients for intravenous βâlactam antibiotics is proposed. We focused on the allometric relationships of pharmacokinetic parameters with individual body weights (BW) in human including healthy adults and pediatric patients. Drug concentration data for 15 intravenous βâlactam antibiotics were collected retrospectively from the published articles and the individual pharmacokinetic parameters were reâcalculated. A mixed effect modeling (MEM) was applied for the allometric relationship for those βâlactam antibiotics, and mean and variances of interâdrug variability for the allometric parameters and also variance for intraâdrug (residual) variability were estimated. Then drugâspecific allometric parameters were estimated by an empirical Bayesian method using the pharmacokinetic parameters for a drug only in healthy adults as observations, and finally the individual pharmacokinetic parameters in pediatric patients were predicted. The predictability of the method was evaluated by the leaveâoneâout method. We also demonstrated a method for simulating plasma concentration-time profiles in pediatric patients, and the predicted time-course curves generally coincided well with the actual plasma concentration data for the tested drugs. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3125-3139, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 11, November 2007, Pages 3125-3139
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 11, November 2007, Pages 3125-3139
نویسندگان
Kenji Shimamura, Toshihiro Wajima, Yoshitaka Yano,