کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487750 | 1114430 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Improving the Loading and Release of NSAIDs from pHEMA Hydrogels by Copolymerization with Functionalized Monomers
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کلمات کلیدی
pHEMABiomaterials - بیومتریال، بیومواد Biomedical devices - دستگاه های بیومدیکDiclofenac - دیکلوفناکPolymeric drug delivery systems - سیستم های تحویل دارویی پلیمریMaterials science - علم مواد یا دانش موادIbuprofen - قرص ایبوپروفن Hydrogels - هیدروژل هاpoly(hydroxyethyl methacrylate) - پلی (هیدروکسی اتیل متاکریلات)Controlled release/delivery - کنترل انتشار / تحویل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Poly(hydroxyethyl methacrylate), pHEMA, hydrogels are widely used for preparing implants, contact lenses, and other biomedical devices, which in many circumstances should load drugs to deliver them in the adjacent tissues. To enhance the potential of pHEMA hydrogels as nonsteroidal anti-inflammatory drugs (NSAIDs) delivery systems, 4-vinyl-pyridine (VP) and N-(3-aminopropyl) methacrylamide (APMA) were incorporated to the network (25-150 mM). The incorporated monomers did not change the viscoelastic properties neither the state of water, but remarkably increased the amount of ibuprofen (up to 10-fold) and diclofenac (up to 20-fold) loaded. Dried loaded pHEMA-APMA and pHEMA-VP hydrogels quickly swelled in water but ionic/hydrophobic interactions prevented the amount of drug released to be above 10%. By contrast, once the water-swollen hydrogels were transferred to pH 5.8 or 8.0 phosphate buffers or NaCl solutions, the release was prompted by competition with ions of the medium. The remaining of hydrophobic interactions and the high polymeric density of the pHEMA hydrogels contributed to sustain the release process for at least 24Â h for ibuprofen and almost 1 week for diclofenac. The release rate was independent of the salt content and pH in the physiological range of values, which enables the design of hydrogel-based delivery systems with predictable release rate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 4, April 2007, Pages 802-813
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 4, April 2007, Pages 802-813
نویسندگان
Paula Andrade-Vivero, Elena Fernandez-Gabriel, Carmen Alvarez-Lorenzo, Angel Concheiro,