کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488025 | 1114450 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation
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کلمات کلیدی
PVPAmorphous - آمورفEnalapril maleate - انالاپریل مالهSecond harmonic generation - تولید هارمونیک دومSolid state - حالت جامدPhysical characterization - خصوصیات فیزیکیRanitidine hydrochloride - رانیتیدین هیدروکلرایدOptical nonlinearity - غیر خطی نوریLactose - لاکتوزPolymorphism - پلی مورفیسمCrystallinity - کریستالی شدن یا تبلور
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be â¼1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 4, April 2006, Pages 761-768
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 4, April 2006, Pages 761-768
نویسندگان
Chris B. Rawle, Chris J. Lee, Clare J. Strachan, Keith Payne, Peter J. Manson, Thomas Rades,