کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2488105 1114456 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crystallization of sucrose glass under ambient conditions: Evaluation of crystallization rate and unusual melting behavior of resultant crystals
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Crystallization of sucrose glass under ambient conditions: Evaluation of crystallization rate and unusual melting behavior of resultant crystals
چکیده انگلیسی
Isothermal crystallization of sucrose glass under ambient condition was investigated by powder X-ray diffraction, isothermal microcalorimetry, and water sorption/desorption analysis. Isothermal microcalorimetry measurements showed that the crystallization behavior was affected by the compression force applied to starting amorphous materials. The crystallization rate was analyzed by X-ray diffraction measurements to establish that the rate could well be explained by the Avrami-Erofeev equation. In the water sorption/desorption analysis, the weight change during the crystallization was elucidated by supposing that desorption proceeded from the crystallized part. The sucrose crystallized at relatively low temperature conditions showed completely different melting behavior from that of intact sucrose, although the crystal form was most likely to be identical. This difference could be explained by defects in the lattice structure produced during the crystallization and the desorption process. Correlation was found between the melting temperature and the water content just before the crystallization. Defects in the crystal structure were partially modified by annealing as has been found in relaxation studies of amorphous materials. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 6, June 2006, Pages 1354-1363
نویسندگان
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