کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488223 | 1114470 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Programmed Humidifying in Drug Stability Experiments
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The stability of penicillin potassium, as a solid state model, was investigated by a programmed humidity and temperature controlled method. An optimization calculational approach to data handling is suggested. The stability of drugs which are unstable to both heat and moisture could be studied by a single pair of experiments, one with programmed humidity control and one non-isothermal, rather than many standard isothermal studies, each at constant relative humidity. The controlling system, based on a pocket computer, was found to be accurate and reliable. The results indicated that the kinetic parameters obtained were comparable to those from isothermal studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 11, November 2005, Pages 2531-2540
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 11, November 2005, Pages 2531-2540
نویسندگان
Qiang Zhao, Xiancheng Zhan, Linli Li, Chengrong Li, Tao Lin, Xiaodong Yin, Ning He,