کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493825 1115530 2011 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
چکیده انگلیسی

Endogenous cannabinoids (eCBs) are retrograde messengers that provide feedback inhibition of both excitatory and inhibitory transmission in brain through the activation of presynaptic CB1 receptors. Substantial evidence indicates that eCBs mediate various forms of short- and long-term plasticity in brain regions involved in the etiology of addiction. The present review provides an overview of the mechanisms through which eCBs mediate various forms of synaptic plasticity and discusses evidence that eCB-mediated plasticity is disrupted following exposure to a variety of abused substances that differ substantially in pharmacodynamic mechanism including alcohol, psychostimulants and cannabinoids. The possible involvement of dysregulated eCB signaling in maladaptive behaviors that evolve over long-term drug exposure is also discussed, with a particular focus on altered behavioral responses to drug exposure, deficient extinction of drug-related memories, increased drug craving and relapse, heightened stress sensitivity and persistent affective disruption (anxiety and depression).This article is part of a Special Issue entitled ‘Synaptic Plasticity and Addiction’.


► We describe endocannabinoid-mediated synaptic plasticity in the brain.
► Evidence for drug-induced disruption of this synaptic plasticity is then presented.
► Implications of altered synaptic plasticity in the context of addiction is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 61, Issue 7, December 2011, Pages 1070–1087
نویسندگان
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