کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494988 1115589 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
چکیده انگلیسی

Much of the research on long-term potentiation (LTP) is motivated by the question of whether changes in synaptic strength similar to LTP underlie learning and memory. Here we discuss findings from studies on fear conditioning, a form of associative learning whose neural circuitry is relatively well understood, that may be particularly suited for addressing this question. We first review the evidence suggesting that fear conditioning is mediated by changes in synaptic strength at sensory inputs to the lateral nucleus of the amygdala. We then discuss several outstanding questions that will be important for future research on the role of synaptic plasticity in fear learning. The results gained from these studies may shed light not only on fear conditioning, but may also help unravel more general cellular mechanisms of learning and memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 52, Issue 1, January 2007, Pages 215–227
نویسندگان
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