کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2514013 1118444 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro
چکیده انگلیسی

Xyloketal B is a novel marine compound with unique chemical structure isolated from mangrove fungus Xylaria sp. (no. 2508). Pretreatment with xyloketal B (0.63–40 μM) significantly improved oxLDL (150 μg/ml)-induced injury in human umbilical vein endothelial cells (HUVECs) without either toxic or proliferative effects. Xyloketal B concentration-dependently attenuated oxLDL-induced ROS generation, peroxynitrite formation and decrease of Bcl-2 expression. In addition, xyloketal B significantly inhibited NADPH oxidase activity, as well as mRNA expression of gp91phox and p47phox. Furthermore, xyloketal B alone augmented the production of nitric oxide (NO). Collectively, these data indicate that xyloketal B protects against oxLDL-induced endothelial oxidative injury probably through inhibiting NADPH oxidase-derived ROS generation, promoting NO production and restoring Bcl-2 expression, making it a promising compound for further evaluation in the treatment of atherosclerosis.

A novel marine compound xyloketal B protects against oxidized LDL-induced endothelial cell injury through attenuating ROS generation and promoting NO release.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 78, Issue 8, 15 October 2009, Pages 941–950
نویسندگان
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