کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2514660 | 1118477 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C)
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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![عکس صفحه اول مقاله: Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C) Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C)](/preview/png/2514660.png)
چکیده انگلیسی
Unlike polyribonucleotides, such as poly(I:C), chlorite-oxidized oxyamylose (COAM) has been poorly characterized as a polyanionic antiviral. COAM possesses a controversial interferon (IFN)-inducing capacity and its mechanism of action has not been elucidated. In this study, COAM was biochemically characterized and fractionated according to molecular mass. In comparison with a strong IFN induction and upregulation of the helicase RIG-I and MDA-5 mRNAs by poly(I:C), COAM did not enhance IFN-α or -β and IFN-inducible RNA helicases in mouse fibroblastoid cells. Instead, COAM inhibited virus entry by blocking the attachment to the cells. These results suggest that COAM can alter the outcome of infection, not by IFN induction and in turn modifying the cellular antiviral state, but through inhibition of virus entry into cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 76, Issue 7, 1 October 2008, Pages 831-840
Journal: Biochemical Pharmacology - Volume 76, Issue 7, 1 October 2008, Pages 831-840
نویسندگان
Sandra Li, Erik Martens, Chris Dillen, Philippe E. Van den Steen, Ghislain Opdenakker,