کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2514714 1118480 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Signal transduction and regulation: Are all α1-adrenergic receptor subtypes created equal?
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Signal transduction and regulation: Are all α1-adrenergic receptor subtypes created equal?
چکیده انگلیسی

The current manuscript reviews the evidence whether and how subtypes of α1-adrenergic receptors, i.e. α1A-, α1B- and α1D-adrenergic receptors, differentially couple to signal transduction pathways and exhibit differential susceptibility to regulation. In both regards studies in tissues or cells natively expressing the subtypes are hampered because the relative expression of the subtypes is poorly controlled and the observed effects may be cell-type specific. An alternative approach, i.e. transfection of multiple subtypes into the same host cell line overcomes this limitation, but it often remains unclear whether results in such artificial systems are representative for the physiological situation. The overall evidence suggests that indeed subtype-intrinsic and cell type-specific factors interact to direct α1-adrenergic receptor signaling and regulation. This may explain why so many apparently controversial findings have been reported from various tissues and cells. One of the few consistent themes is that α1D-adrenergic receptors signal less effectively upon agonist stimulation than the other subtypes, most likely because they exhibit spontaneous internalization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 73, Issue 8, 15 April 2007, Pages 1097–1106
نویسندگان
, ,