کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2515357 1118514 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deregulated NF-κB activity in haematological malignancies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Deregulated NF-κB activity in haematological malignancies
چکیده انگلیسی

The NF-κB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-κB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-κB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 72, Issue 9, 30 October 2006, Pages 1069–1080
نویسندگان
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