کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2515529 1118529 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Redefining penems
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Redefining penems
چکیده انگلیسی

The antimicrobial class of penems has the potential to address most of the relevant resistance issues associated with β-lactam antibiotics because of their exceptionally broad spectrum of antibacterial activity and their intrinsic stability against hydrolytic attack by many β-lactamases including ESBL and AmpC enzymes. The subclass of carbapenems covers the spectrum of hospital pathogens whereas the subclass of penems covers community pathogens. The only currently available penem, faropenem, has a low propensity for resistance development, β-lactamase induction and selection of carbapenem-resistant Pseudomonas aeruginosa. This makes it attractive for the treatment of community-acquired infections and for step-down or sequential therapy following carbapenem treatment without jeopardizing the activity of carbapenems or the entire β-lactam class in the hospital environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 71, Issue 7, 30 March 2006, Pages 1085–1095
نویسندگان
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