Inhibition of glucose efflux from human erythrocytes by hashish components

Glucose efflux from human erythrocytes under zero-trans conditions is inhibited by the hashish components Δ′-tetrahydrocannabinol and cannabidiol at concentrations above 5 × 10−7 M. The inhibitory effect is rapid and apparently readily reversible. Increasing concentrations of alcohols up to 20 mM do not change the rate of glucose efflux but they do amplify the extent of efflux inhibition by a given dose of hashish component. Methanol, ethanol and propanol show this amplifying effect in a decreasing order.