کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2523740 1557962 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer
چکیده انگلیسی

MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 80, May 2016, Pages 109–114
نویسندگان
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