کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2524427 | 1119566 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 67, Issue 6, July 2013, Pages 527–532
Journal: Biomedicine & Pharmacotherapy - Volume 67, Issue 6, July 2013, Pages 527–532
نویسندگان
Hatice Demet Kiper, Burcin Tezcanli Kaymaz, Aysun Adan Gokbulut, Nur Selvi, Cigir Biray Avci, Buket Kosova, Guniz Iskender, Melis Kartal Yandim, Cumhur Gunduz, Fahri Sahin, Yusuf Baran, Guray Saydam,