کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2524542 1557960 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ursolic acid regulates aging process through enhancing of metabolic sensor proteins level
ترجمه فارسی عنوان
اسید اور اسولیک از طریق افزایش سطح پروتئین های سنسور متابولیک فرایند پیری را تنظیم می کند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

We previously reported that Ursolic Acid (UA) ameliorates skeletal muscle performance through satellite cells proliferation and cellular energy status. In studying the potential role of the hypothalamus in aging, we developed a strategy to pursue UA effects on the hypothalamus anti-aging proteins such as; SIRT1, SIRT6, PGC-1β and α-Klotho.In this study, we used a model of aging animals (C57BL/6). UA dissolved in Corn oil (20 mg/ml) and then administrated (200 mg/Kg i.p injection) to mice, twice daily for 7 days. After treatment times, the mice perfused and the hypothalamus isolated for preparing of tissue to Immunofluorescence microscopy.The data illustrated that UA significantly increased SIRT1 (∼3.5 ± 0.3 folds) and SIRT-6 (∼1.5 ± 0.2 folds) proteins overexpression (P< 0.001). In addition, our results showed that UA enhanced α-Klotho (∼3.3 ± 0.3) and PGC-1β (∼2.6 ± 0.2 folds) proteins levels (P < 0. 01). In this study, data were analyzed using SPSS 16 (ANOVA test).To the best of our knowledge, it seems that UA through enhancing of anti-aging biomarkers (SIRT1 and SIRT6) and PGC-1β in hypothalamus regulates aging-process and attenuates mitochondrial-related diseases. In regard to the key role of α-Klotho in aging, our data indicate that UA may be on the horizon to forestall diseases of aging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 82, August 2016, Pages 8–14
نویسندگان
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