کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2524542 | 1557960 | 2016 | 7 صفحه PDF | دانلود رایگان |
We previously reported that Ursolic Acid (UA) ameliorates skeletal muscle performance through satellite cells proliferation and cellular energy status. In studying the potential role of the hypothalamus in aging, we developed a strategy to pursue UA effects on the hypothalamus anti-aging proteins such as; SIRT1, SIRT6, PGC-1β and α-Klotho.In this study, we used a model of aging animals (C57BL/6). UA dissolved in Corn oil (20 mg/ml) and then administrated (200 mg/Kg i.p injection) to mice, twice daily for 7 days. After treatment times, the mice perfused and the hypothalamus isolated for preparing of tissue to Immunofluorescence microscopy.The data illustrated that UA significantly increased SIRT1 (∼3.5 ± 0.3 folds) and SIRT-6 (∼1.5 ± 0.2 folds) proteins overexpression (P< 0.001). In addition, our results showed that UA enhanced α-Klotho (∼3.3 ± 0.3) and PGC-1β (∼2.6 ± 0.2 folds) proteins levels (P < 0. 01). In this study, data were analyzed using SPSS 16 (ANOVA test).To the best of our knowledge, it seems that UA through enhancing of anti-aging biomarkers (SIRT1 and SIRT6) and PGC-1β in hypothalamus regulates aging-process and attenuates mitochondrial-related diseases. In regard to the key role of α-Klotho in aging, our data indicate that UA may be on the horizon to forestall diseases of aging.
Journal: Biomedicine & Pharmacotherapy - Volume 82, August 2016, Pages 8–14