کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2524664 1557959 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Poly-carboxylic acids functionalized chitosan nanocarriers for controlled and targeted anti-cancer drug delivery
ترجمه فارسی عنوان
پلی کربوکسیلیک اسید نانوذرات کیتوزان را برای تحویل داروهای کنترل شده و هدفمند ضدعفونی کرده است
کلمات کلیدی
کیتوزان، سیس پلاتین، تحویل مواد مخدر، نانوکامپوزیت ها، پلی اکسالیت، ژئولیت یونیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

The present study evaluates the in-vitro cisplatin (CDDP) release from four different poly oxalates cross-linked chitosan (CS) nanocomposites. The poly oxalates were synthesized from the reaction of four different dicarboxylic acids with ethylene glycol (EG). The encapsulation of CDDP on CS cross-linked with Oxalic acid-EG, Succinic acid-EG, Citric acid-EG and tartaric acid-EG carriers were carried out by the ionic gelation technique. The poly-oxalate nanocarriers were characterized by scanning electron microscopy, atomic force microscopy, X-ray diffraction studies and zeta potential analysis. The stability of poly-oxalates was calculated by the density functional theory (DFT) using Gaussview 05. Excellent drug release kinetics and good biocompatibility of nanocomposites were observed for the in-vitro analysis. The unloaded poly oxalate nanocomposites perform to have a low inherent cytotoxicity, whereas the loaded nanocomposites were as active as free CDDP in the MCF-7 cancer cell line. The tumor growth inhibitions of CDDP-loaded nanocomposites are more or equal to that of free CDDP. Taken together, these two poly oxalate nanocomposites are established as promising drug carriers for the delivery of CDDP.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 83, October 2016, Pages 201–211
نویسندگان
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