کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2524711 1557959 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro—Scientific evaluation on antimicrobial, antioxidant, cytotoxic properties and phytochemical constituents of traditional coastal medicinal plants
ترجمه فارسی عنوان
در آزمایشگاهی، ارزیابی علمی بر خواص ضد میکروبی، آنتیاکسیدانی، سیتوتوکسیک و ترکیبات فیتوشیمیایی گیاهان دارویی ساحلی سنتی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی


• In vitro scientific evaluation of traditional Coastal Medicinal Plants (CMP’s) was performed.
• Methanolic extract of CMP’s showed excellent antimicrobial, antioxidant, antihemolytic properties.
• The methanolic extract had also showed good cytotoxicity against A. salina larvae.
• Bioassay guided active fraction was identified as flavanoids and terpenoids.

In the present study, evaluation of antimicrobial, antioxidant, phytochemical constituents and toxicological properties of six coastal medicinal plants (CMP’s) such as Ipomea biloba, Cantharanthus roseus, Cymbopogon citratus, Vitex negundo, Thespesia populnea and Pandanus tectorius was done. The maximum antimicrobial activity was recorded by methanolic extracts of V. negundo and T. populnea against bacterial and fungal pathogens. Similarly, methanolic extracts of V. negundo and T. populnea evidenced highest antioxidant properties. The extract of T. populnea showed the maximum cytotoxicity against Artemia salina with the LC50 value of 478.11 μg/ml. The hemolytic property of CMP’s extracts was V. negundo (8.91%), T. populnea (21%) and C. citratus (64%) also the hemolytic index did not show any hemolysis of human erythrocytes. Furthermore, the TLC separation of V. negundo and T. populnea extracts exhibited the presence of Flavonoids (Rf-0.74) and Terpenoids (Rf-0.64). The present findings propose the promising clinical applications of selected CMP’s.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 83, October 2016, Pages 648–657
نویسندگان
, , , , , ,