کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2524776 | 1119580 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Stage dependent destructuration of neuro-endocrine-immune system components in lung cancer patients Stage dependent destructuration of neuro-endocrine-immune system components in lung cancer patients](/preview/png/2524776.png)
BackgroundClose relationships among the nervous, endocrine and immune system components maintain body homeostasis. Alteration of time-related prophile of variation of system components and loss of integrated function may favour the developing of cancer and may be aggravated in the presence of neoplastic disease. The aim of our study was to evaluate the prophiles of time-related variation of neuro-endocrine-immune system components in lung cancer patients.MethodsPeripheral blood samples were collected at intervals of 4 hours for 24 hours from 11 healthy subjects (age range 35–53 years, mean age ± s.e. 43.6 ± 1.7) and nine patients suffering from nonsmall cell lung cancer (age range 43–63 years, mean age ± s.e. 51.0 ± 2.4). In each blood sample, lymphocyte subpopulations (CD3, CD4, CD8, HLA-DR, CD16, CD20, CD25, γδTcR) were analyzed and melatonin, cortisol, TRH, TSH, free thyroxine, GH, IGF1 and interleukin IL2 on serum were measured.ResultsIn our I–II stage lung cancer patients CD8+ lymphocytes (P = 0.01), and in particular the T suppressor subset (P < 0.0001), CD20+ cells (P = 0.05), γδTCR expressing cells (P < 0.01) and IGF1 (P = 0.004) were diminished, whereas CD16+ cells (P < 0.0001), CD25+ cells (P = 0.03), free thyroxine (P = 0.001) and GH (P < 0.0001) were increased in respect of healthy subjects. In our III–IV stage lung cancer patients CD8+ lymphocytes (P = 0.003) and in particular the T suppressor subset (P < 0.0001), CD20+ cells (P = 0.05), γδTCR expressing cells (P = 0.01), melatonin (P = 0.03), TSH (P = 0.006) and IGF1 (P < 0.0001) were diminished, whereas CD4+ cells (P = 0.002), CD16+ cells (P < 0.0001), CD25+ cells (P = 0.002), cortisol (P = 0.003), TRH (P = 0.004), free thyroxine (P = 0.001), GH (P < 0.0001) and IL2 (P = 0.0002) were increased in respect of healthy subjects. A statistically significant difference was evidenced between the two groups of cancer patients for the values of CD16+ cells (P < 0.0001), free thyroxine (P = 0.001) and IGF1 (P < 0.0001) higher in I–II stage lung cancer patients and for the values of CD4+ cells (P < 0.0001), γδTCR expressing cells (P = 0.002), TRH (P = 0.002) and IL2 (P = 0.01) higher in III–IV stage lung cancer patients. Lung cancer patients showed alteration of the pattern of circadian variation of CD3+, CD8+, CD8+ dim, CD16+, CD20+ and γδTCR expressing cells and of cortisol, TSH and GH serum levels. Pair-wise comparisons showed severe and stage dependent alterations in lung cancer patients.ConclusionsThe prophiles of time-related variation of neuro-endocrine-immune system components are altered in a stage dependent manner in lung cancer patients and this alteration may impair the customary integrated system function.
Journal: Biomedicine & Pharmacotherapy - Volume 65, Issue 1, February 2011, Pages 69–76