کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2525122 1119596 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells
ترجمه فارسی عنوان
پنتوکسیفیلین چسبندگی سلولی و گیرنده های متحرک آن را به مولکول های ماتریکس خارج سلولی در سلول های سرطان پستان تنظیم می کند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Being an inhibitor of platelet aggregation, it can thus reduce the adhesiveness of cancer cells prolonging their circulation time. This delay in forming secondary tumours makes them more prone to immunological surveillance. Recently, we have evaluated its anti-metastatic efficacy against breast cancer, using MDA-MB-231 model system. In view of this, we had ascertained the effect of PTX on adhesion of MDA-MB-231 cells to extracellular matrix components (ECM) and its allied receptors such as the integrins. PTX affected adhesion of breast cancer cells to matrigel, collagen type IV, fibronectin and laminin in a dose dependent manner. Further, PTX showed a differential effect on integrin expression profile. The experimental metastasis model using NOD-SCID mice showed lesser tumour island formation when treated with PTX compared to the control. These findings further substantiate the anti-adhesive potential of PTX in breast cancer and warrant further insights into the functional regulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 68, Issue 1, February 2014, Pages 93–99
نویسندگان
, ,