کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2525772 | 1119630 | 2007 | 6 صفحه PDF | دانلود رایگان |
The effects of the anticancer drug irinotecan combined with ethanolic extract of propolis (EEP), a water-soluble derivate of propolis (WSDP), quercetin and naringin on the growth of Ehrlich ascites tumor (EAT) and the life span of tumor-bearing Swiss albino mice were studied. Test components were given to mice intraperitoneally (i.p.) at doses of 100 mg kg−1 for three consecutive days before the i.p. injection of EAT cells (1 × 106). Irinotecan was administered i.p. at dose of 50 mg kg−1 on days 1, 13, and 19 after tumor cell inoculation. The results clearly demonstrate the synergistic action of irinotecan and EEP on survival time. These results suggest that clinical trials using a propolis preparation EEP combined with irinotecan may be beneficial in maximizing antitumor activity and minimizing post-chemotherapeutic reactions to the cytostatic drug.
Journal: Biomedicine & Pharmacotherapy - Volume 61, Issue 5, June 2007, Pages 292–297