کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2529770 1558122 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptome profiling in Parkinson's leukocytes: from early diagnostics to neuroimmune therapeutic prospects
ترجمه فارسی عنوان
پروفیل ترانسکتوموم در لکوسیت های پارکینسون: از تشخیص زودهنگام به چشم انداز درمانی نوروئومون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Currently late Parkinson's disease diagnosis only allows palliative treatment.
• Studies in patients and animal models implicate neuroimmune malfunctioning.
• RNA-sequencing and microarray analyses indicate RNA-mediated neuroimmune errors.
• New technologies may identify peripheral neuroimmune-related disease biomarkers.
• Interference with neuroimmune mediators may enable curative treatment.

Parkinson's disease (PD) involves motor symptoms reflecting the progressive degeneration of dopaminergic neurons in the substantia nigra. However, diagnosis is only enabled late in the disease, limiting treatment to palliative assistance. Here, we review recently generated transcriptional profiling datasets from blood and brain RNA of human PD cohorts and animal models that may offer unprecedented progress in PD research. Specifically, advanced analysis techniques demonstrated functionally inter-related underlying impairments of RNA metabolism and neuroimmune signalling processes. Identifying novel biomarkers in serum and nucleated blood cells, including protein networks and non-coding RNAs can drive discovery of the molecular mechanisms involved and reveal new targets for therapeutic intervention, posing a dual diagnosis/treatment opportunity for limiting the exacerbation of neuroinflammatory events in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 26, February 2016, Pages 102–109
نویسندگان
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