کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2529841 1558126 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltage-gated sodium channels
ترجمه فارسی عنوان
کانال های سدیم با ولتاژ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Voltage-gated sodium channels (NaV) play a key role in neuronal excitability.
• Individual nerves express multiple NaV subtypes.
• Many NaV mutations are associated with gain or loss of function.
• Efforts are underway to develop NaV subtype-specific NaV blockers.

Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate signaling for a number of clinical indications by taking advantage of this specific distribution of channel isoforms. This review highlights recent advances in the study of human channelopathies, animal toxins and channel structure that may facilitate the development of selective voltage-gated sodium channel blockers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 22, June 2015, Pages 131–139
نویسندگان
, ,