Endocrine disruptive compounds and cardio-metabolic risk factors in children

• In children phthalates, BPA, DES, PCB, BPA, smoking, linked to adiposity.
• Inconclusive evidence DDE, fungicides, dioxin, phytoestrogens, PFAS, lead, arsenic.
• Less studied PBDE, organotins.

The endocrine disrupting chemicals (EDC) are exogenous chemicals that can disrupt hormonal signaling system. EDCs are ubiquitous in our environment and many EDC are detectable in humans. With the increasing obesity prevalence in children it is imperative to explore the role of EDC as obesogens. This review summarizes recent epidemiological evidence regarding impact of these EDC on weight gain and metabolic outcomes in children. The EDCs include pharmaceuticals, pesticides, industrial by-products, and cigarette smoke. Current evidence suggests a link between early life exposure to some industrial by-products, synthetic hormones and cigarette smoke with weight gain. However, there is inconclusive evidence of an association between exposure to fungicides, dioxin, phytoestrogens, flame retardants, heavy metals and childhood obesity.