Salidroside liposome formulation enhances the activity of dendritic cells and immune responses

• Salidroside liposome could promote mature, stimulating proliferation of MLR and antigen presentation of DC cells in vitro.
• Salidroside liposome enhanced the immune response in vivo.
• Immunological adjuvant of salidroside liposome is better than those of salidroside and liposome.

Salidroside, the important composition, of Rhodiola rosea L. has been reported to have various pharmacological properties. Liposome is known to be effective as drug carriers and immune adjuvant. Therefore, the aim of this study is to investigate immunological adjuvant activity of salidroside liposome. Here we reported the preparation, the effect on DCs in vitro and the immune response in vivo. The immunological adjuvant activity of salidroside liposome formulation was compared with that of salidroside and liposome. The result showed that salidroside liposome formulation not only could promote the maturation of DCs, the stimulation of DCs on MLR proliferation and the antigen presenting ability, but also induced the sustained cellular immune and humoral immune response. Overall, the results showed that salidroside liposome formulation had the potential to act as effective sustained release vaccine delivery systems.