Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC – oxidized cellulose, NaOC – oxidized cellulose sodium salt, DAC – dialdehyde cellulose, CMC – carboxymethyl cellulose, MFC – microfibrilated cellulose, and MCC – microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-α. The study provides evidence that DAC exerts a marked effect on the induction of TNF-α gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers.