کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2541477 | 1122659 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A highly branched 1,3-β-d-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A highly branched 1,3-β-d-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes A highly branched 1,3-β-d-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes](/preview/png/2541477.png)
چکیده انگلیسی
We recently elucidated the structure of a highly branched 1,3-β-d-glucan with 6-monoglucopyranosyl side chains, extracted from Aureobasidium pullulans (AP-FBG). Although the biological effects of β-d-glucans are known to depend on their structures, the effects of a highly branched 1,3-β-d-glucan on the production of cytokines by leukocytes in mice have not yet been elucidated. In this study, we found that AP-FBG strongly induced the production of various cytokines, especially Th1 cytokines (e.g., IFN-γ and IL-12p70) and Th17 cytokines (e.g., IL-17A), but did not induce the production of IL-4, IL-10, and TNF-α in DBA/2 mouse-derived splenocytes in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 9, Issue 12, November 2009, Pages 1431–1436
Journal: International Immunopharmacology - Volume 9, Issue 12, November 2009, Pages 1431–1436
نویسندگان
Rui Tada, Masashi Yoshikawa, Takao Kuge, Asuka Tanioka, Ken-ichi Ishibashi, Yoshiyuki Adachi, Kazufumi Tsubaki, Naohito Ohno,