کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2544816 1560381 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties
چکیده انگلیسی

Ethnopharmacological relevanceMorelos State is one of the most important regions of Mexico where several plant species are used in traditional medicine to influence central nervous system (CNS) activity; for example Tagetes lucida Cav.Aim of the studyTo investigate the ethnobotany, phytochemistry and pharmacology of the tranquilizing properties of T. lucida aerial parts.Material and methodsData on the medicinal uses of T. lucida were explored by interviewing healers and merchants of local markets in different regions of Morelos State by using a questionnaire. Anxiolytic and/or sedative-like responses of the T. lucida were investigated in experimental models in mice such as: open-field, exploration cylinder, hole-board, plus-maze, and the barbituric-induced hypnosis potentiation. The possible mechanism of action was explored in the presence of WAY100635 (0.32 mg/kg, i.p.) and flumazenil (10 mg/kg, i.p.) antagonists. A feasible active compound was isolated and identified by using conventional chromatography, including UHPLC and MS (DART) [M+H]+ techniques.ResultsInterviews of healers and merchants from ten local regions of Morelos State showed that they recommended T. lucida as infusion and as tincture for several culture-bound syndromes associated with the CNS. Anxiolytic and sedative-like activities of polar extracts were corroborated in the experimental models; these effects were inhibited in the presence of 5-HT1A and GABA/BDZ receptor antagonists. Dimethylfraxetin was identified as one possible active compound.ConclusionsThe results support the anxiolytic and sedative-like properties of T. lucida in traditional medicine by involving serotonergic and GABAergic neurotransmission and coumarinic constituents.

Fractionation of an ethanol extract of Tagetes lucida aerial parts following the anxiolytic and sedative-like activities to obtain active compounds of coumarin natureFigure optionsDownload high-quality image (190 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 181, 2 April 2016, Pages 221–228
نویسندگان
, , , , , ,