کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545747 1123998 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf
چکیده انگلیسی

Ethnopharmacological relevanceBauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueous extract.Materials and methodsThe Bauhinia purpurea aqueous extract (BPAE) was prepared in the doses of 100, 500 and 1000 mg/kg. Antiulcer activity of BPAE was evaluated by absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation models. Acute toxicity was also carried out.ResultsBPAE, at the dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally. Oral administration of BPAE exhibited antiulcer activity (p < 0.05) in all models used. However, the dose-dependent activity was observed only in the absolute ethanol-induced gastric ulcer model. Histological studies supported the observed antiulcer activity of BPAE. In pyloric ligation assay, BPAE increased the gastric wall mucus secretion.ConclusionsThe BPAE exhibits antiulcer activity, which could be due to the presence of saponins or sugar-free polyphenols, and, thus, confirmed the traditional uses of Bauhinia purpurea in the treatment of ulcers.

The aqueous extract of Bauhinia purpurea (Fabaceae) exhibited antiulcer activity, which could be associated with its anti-inflammatory and antioxidant activities, and the presence of saponins.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 137, Issue 2, 2 September 2011, Pages 1047–1054
نویسندگان
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