Identification of anti-inflammatory target genes of Rhizoma coptidis extract in lipopolysaccharide-stimulated RAW264.7 murine macrophage-like cells

The anti-inflammatory target genes of Rhizoma coptidis extract (CEX) were identified by analyzing the differential gene expression profiles of LPS-stimulated RAW264.7 cells treated with CEX. The results revealed various genes associated with inflammatory responses, which included cell surface and signaling molecules as well as cytokine genes that have not been recognized in previous studies. These data support the traditional use of CEX as an anti-inflammatory agent and should provide useful information for the understanding of the pharmacological effects of CEX.