کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546453 1124027 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana
چکیده انگلیسی

Ethnopharmacological relevanceThe roots and rhizomes of Clematis are commonly used as an analgesic, abirritative, antibacterial, antiphlogistic, anticancer and diuretic agent. The Naxi people traditionally used Clematis ganpiniana's (Lévl. Et Vant.) as a diuretic agent, an anti-inflammatory and anticancer remedy.Aim of studyTo investigate the cytotoxic and antibacterial components from Clematis ganpiniana.Materials and methodsThe aboveground part of Clematis ganpiniana was isolated by chromatographic techniques. Structures of isolated compounds were identified by spectroscopic methods and comparison with published data. Their cytotoxic, apoptosis and antibacterial activities of purified components were also performed.ResultsBy bioassay-guided fractionation techniques and chemical characterization, four triterpene glycosides were isolated and their cytotoxicity against cancer cells and antibacterial activity were tested. They showed significant inhibitory activities against MCF-7, MDA-MB-231 with IC50 value of 0.7–16.5 μg/ml, and significant apoptosis for MCF-7 and MDA-MB-231. Moreover, compound 4 showed weak wide-spectrum antibacterial activity.ConclusionThese results provide promising baseline information for the potential use of Clematis ganpiniana as well as some of the isolated compounds in the treatment of cancer and infectious disease.

From a biologically active extract from the Clematis ganpiniana, four triterpene glycosides 1–4 were isolated.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 126, Issue 3, 10 December 2009, Pages 382–385
نویسندگان
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