کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546960 1124041 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
چکیده انگلیسی

Aims of the studyGanoderma lucidum possesses significant antioxidant and anti-cancer properties. The effects of Lingzhi antioxidants on oxidative DNA damage and oxidative stress were investigated, in order to understand their roles in bladder chemoprevention.Materials and methodsAntioxidant-enhanced extracts were tested, in terms of ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH·) inhibition, hydrogen peroxide (H2O2) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, and cytotoxicity, using an in vitro pre-cancerous human uroepithelial cell (HUC-PC) tumorigenic model.ResultsWater-soluble extract (GLw) possesses relatively higher antioxidant capacities than the water-insoluble counterpart (GLe); however, under the challenge of carcinogenic 4-aminobiphenyl (ABP), GLw reduced the 8-OHdG concentration in HUC-PC culture, while GLe induced the formation of H2O2 and 8-OHdG in a dose-dependent manner. The modern theory of antioxidant–oxidant balance seems to obey the theory of Yin–Yang in traditional Chinese medicine (TCM).ConclusionsWater-soluble and water-insoluble components of Ganoderma lucidum exhibited dual roles in oxidative DNA damage. Oxidative DNA damage may be an underlying mechanism of Lingzhi-induced apoptosis in bladder chemoprevention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 118, Issue 2, 23 July 2008, Pages 324–330
نویسندگان
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