کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2547947 | 1124074 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis—A flow cytometric study Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis—A flow cytometric study](/preview/png/2547947.png)
Bergenin (1), a C-glycoside of 4-O-methyl gallic acid, isolated from rhizomes of Bergenia stracheyi (Saxifragaceae) and its O-demethylated derivative norbergenin (2), prepared from 1, are reported to show anti-arthritic activity through possible modulation of Th1/Th2 cytokine balance. Flow cytometric study showed that the oral administration of 1 and 2 at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2, IFN-γ and TNF-α) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice. This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity. At similar dose levels, the effect of 2 was found to be more than that of 1. The oral LD0 for 1 and 2 was more than 2000 mg/kg body weight of the mice.
Journal: Journal of Ethnopharmacology - Volume 112, Issue 2, 13 June 2007, Pages 401–405