کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548248 1124092 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam
چکیده انگلیسی

Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria. Bioassay-guided extractions of Zanthoxylum rhoifolium bark have shown that antiplasmodial activity is concentrated in the alkaloid fraction. Further fractionation of this extract has yielded seven benzophenanthridine alkaloids, dihydroavicine 1, dihydronitidine 2, oxyavicine 3, oxynitidine 4, fagaridine 5, avicine 6 and nitidine 7. Antimalarial activity of the last five compounds has been evaluated, and nitidine was the most potent, displaying an IC50 < 0.27 μM against Plasmodium falciparum.Investigation of the traditional remedy, a trunk bark decoction in water, has shown that fagaridine 5, avicine 6 and nitidine 7 are also present in the decoction, therefore justifying the traditional use of Zanthoxylumrhoifolium bark as antimalarial.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 106, Issue 3, 19 July 2006, Pages 348–352
نویسندگان
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