کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548529 1124122 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiplasmodial activity of Cylicodiscus gabunensis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antiplasmodial activity of Cylicodiscus gabunensis
چکیده انگلیسی

The antimalarial activity of ethanolic stembark extract of Cylicodiscus gabunensis was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections as well as for repository activity. The LD50 of the extract was determined to be 223.6 mg/kg, while doses of 250 mg/kg and above were found to be lethal to mice. Cylicodiscus gabunensis extract (20–60 mg/kg/day) exhibited a significant (P < 0.05) blood schizontocidal activity in 4-day early infection, repository evaluation and in established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The stembark extract possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 107, Issue 2, 19 September 2006, Pages 175–178
نویسندگان
, , ,