کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561184 1560834 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
E3 ubiquitin ligases as novel targets for inflammatory diseases
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
E3 ubiquitin ligases as novel targets for inflammatory diseases
چکیده انگلیسی

Ubiquitination is one of the post translational modifications which decide the fate of various proteins in the cells, by either directing them towards proteasomal degradation or participation in several cell signalling pathways. Recently, the role of ubiquitination has been unravelled in pathogenesis and progression of various diseases, where inflammation is critical, like obesity, insulin resistance, atherosclerosis, angiotensin-II induced cardiac inflammation and asthma. E3 ligases are known to be instrumental in regulation of the inflammatory cascade. This review focuses on the role of different E3 ligases in the development of inflammatory diseases and thus may help us to target these E3 ligases in future drug discovery to prevent inflammation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 106, April 2016, Pages 1–9
نویسندگان
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